This standard provides a common framework for distributed ledger technology (DLT) usage, implementation, and interaction in healthcare and the life and social sciences, addressing scalability, security and privacy challenges. DLT tokens, smart contracts, transactions, assets, networks, off-chain data storage and access architectural patterns, and both permissioned and permission-less DLT are included in the framework. (This standard incorporates open source. See https://opensource.ieee.org/standards/project/)